East of 101 (industrial) South San Francisco Homes and Neighborhood Guide

South San Francisco neighborhood guide

East of US 101, South San Francisco is mostly the flat research and development district the city is known for, home to Genentech and many other biotech companies.

This MLS area also takes in a small number of homes and condos near East Grand Avenue, Oyster Point Boulevard and South Linden Avenue.

For buyers who work in the biotech district, condos here are among the most attainable on the Peninsula, with Oyster Point Marina and the Bay Trail close by.

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Top photo: Derrick Coetzee, CC0, via Wikimedia Commons

East of 101 (industrial) is shaded. Borders follow MLSListings area lines. Zoom in for street detail, or browse all neighborhood guides.

At a glance

  • Biotech and R&D district east of US 101
  • Median condo sale about $635K over the last 12 months (7 sales, MLSListings)
  • Few homes; mostly condos and townhomes
  • Near East Grand Avenue and Oyster Point Boulevard
  • Oyster Point Marina and Park on the Bay

Homes and Streets

Housing here is limited and mostly condominiums and townhomes, with only a handful of single family sales each year.

Because much of the area is industrial and near the Bay, check zoning, nearby uses and flood maps for any address you are considering.

See current homes for sale in South San Francisco →

Video Tours

I have not filmed a walkthrough in East of 101 (industrial) yet. Want me to tour a home here for you? Send me the address, and see my other walkthroughs below.

See all of my home tours on Instagram →

Parks and Open Space

Oyster Point Marina and ParkCity owned 408 berth marina and 33 acre park with trails, a fishing pier and small beaches.
Point San Bruno ParkBayfront park next to the biotech campuses.

Public Schools Nearby

South San Francisco Unified School DistrictServes South San Francisco, including South San Francisco High School.
Martin ElementarySouth San Francisco Unified elementary school west of US 101.

Confirm the school for a specific address with the district.

Nearby Neighborhoods

East of 101 (industrial) FAQ

Are there homes east of 101 in South San Francisco?

A few. The area is mainly the city's biotech and R&D district, but this MLS area recorded 7 condo sales and 7 house sales over the last 12 months.

What do condos sell for here?

The median condo sale was about $635,000 over the 12 months ending November 8, 2026, across 7 sales in MLSListings.

What is nearby?

Oyster Point Marina and Park, the Bay Trail and the biotech campuses, including Genentech.

How can I find homes for sale in East of 101 (industrial)?

Browse current listings in South San Francisco on Joseph Suarez's site, or join his off-market list to hear about homes before they are listed publicly. Thinking of selling? Request a free home valuation for a local estimate based on recent nearby sales.

Thinking about East of 101 (industrial)?

Whether you are buying or selling, Joseph Suarez can walk you through recent sales, street by street pricing and what is coming up before it hits the market.

See homes for saleWhat is my home worth?Get off-market listingsContact Joseph

← Back to South San Francisco neighborhoods · South San Francisco city guide and market report or browse all Peninsula neighborhoods

Updated November 2026 by Joseph Suarez, Realtor with Coldwell Banker in Burlingame, DRE 02085594.

Sources: South San Francisco, California (Wikipedia), Oyster Point Marina/Park (Wikipedia), South San Francisco Unified School District (Wikipedia), MLSListings closed sales, November 9, 2025 to November 8, 2026. Information is believed accurate but not guaranteed.